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Mechanistic studies have established that Dihexas procognitive and synaptogenic effects are mediated by the hepatocyte growth factor (HGF) / c-Met receptor system rather than by the classical AT 4 receptor, despite Dihexas structural origin as an angiotensin IV derivative

The cycling approach most protocols recommend partly addresses these uncertainties

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Because certain peptides have negative effects on other healthy cells, such as being highly toxic or altering the immunological response, there are still concerns about the use of ACPs (,)